Publications
2017
Tempone, A.G.; Ferreira, D.D.; Lima L.M.; Silva, T.A.C.; Borborema, S.E.T.; Reima, J.Q.; Galuppo, M.K.; Guerra, J.M.; Russell, A.J.; Wynne, G.M.; Lai, R.Y.L.; Cadelis, M.M.; Copp, B.R. Efficacy of a series of alpha-pyronederivatives against Leishmania (L.) infantum and Trypanosoma cruzi. European Journal of Medicinal Chemistry 2017, 139, 947-960.
Kerr, A.G.; Tam, L.C.S.; Hale, A.B.; Cioroch, M.; Douglas, G.; Agkatsev, S.; Hibbitt, O.; Mason, J.; Holt-Martyn, J.; Bataille, C.J.R.; Wynne, G.M.; Channon, K.M.; Russell, A.J. and Wade-Martins, R. A genomic DNA reporter screen identifies squalene synthase inhibitors which act cooperatively with statins to upregulate the low-density lipoprotein receptor. Journal of Pharmacology and Experimental Therapeutics 2017, 361 (3), 417-428.
Partridge, FA.; Murphy, EA.; Willis, NJ.; Bataille, CJR.; Forman, R.; Heyer-Chauhan, N.; Marinič, B.; Sowood, DJC.; Wynne, GM.; Else, KJ.; Russell, AJ.; Sattelle, DB. Dihydrobenz[e][1,4]oxazepin-2(3H)-ones, a new anthelmintic chemotype immobilising whipworm and reducing infectivity in vivo. PLoS Negl Trop Dis 11(2): e0005359. doi:10.1371/ journal.pntd.0005359.
Bataille, CJR.; Brennan, MB.; Byrne, S.; Davies, SG.; Durbin, M.; Fedorov, O.; Huber, KVM,; Jones, AM.; Knapp, S.; Liu, G.; Nadali, A.; Quevedoa, CE.; Russell, AJ.; Walker, RG.; Westwood, R.; Wynne, GW. Thiazolidine derivatives as potent and selective inhibitors of the PIM kinase family.
Bioorganic and Medicinal Chemistry, 2017. http://dx.doi.org/10.1016/j.bmc.2017.02.056
2016
Russell, A.J. and Silpa, L. Chemical-Induced Naive Pluripotency. Cell Chemical Biology, 2016, 23, 532-534. doi:10.1016/j.chembiol.2016.05.002
McIntyre, A.; Hulikova, A.; Ledaki, I.; Snell, C.; Singleton, D.; Steers, G.; Seden, P.; Jones, D.; Bridges, E.; Winfield, S.; Li, J.L.; Russell, A.; Switch, P.; Harris, A.L. Disrupting Hypoxia-Induced Bicarbonate Transport Acidifies Tumor Cells and Suppresses Tumor Growth. Cancer Res 2016, 76, 3744–55
Davies, S. G.; Goddard, E, C.; Roberts, P. M.; Russell, A. J.; Smith, A. D.; Thomson, J. E.; Withey, J. M. Strategies for the construction of morphinan alkaloid AB-rings: regioselective Friedel-Crafts-type cyclisations of γ-aryl-β-benzoylamido acids with asymmetrically substituted γ-aryl rings. Tetrahedron: Asymmetry 2016, 27, 274.
Clunie-O’Connor, C.; Smits, A.M.; Antoniades, C.; Russell, A.J.; Yellon, D.M.; Goumans, M-J.; Riley, P.R. The Derivation of Primary Human Epicardium-Derived Cells. Curren. Protoc. Stem Cell Biol. 2016, 35: 2C.5.1 - 2C.5.x.
Zervou, S.; Whittington, H.J.; Russell, A.J. and Lygate, C.A. Augmentation of creatine in the heart. Mini-reviews in Medicinal Chemistry. 2016, 16, 19-28.
2015
Guiraud, S.; Squire, S. E.; Edwards, B.; Chen, H.; Burns, D. T.; Shah, N.; Babbs, A.; Davies, S. G.; Wynne, G. M.; Russell, A. J.; Elsey, D.; Wilson, F. X.; Tinsley, J. M.; Davies, K. E.
Second-generation compound for the modulation of utrophin in the therapy of DMD.
Hum. Mol. Genet. 2015, doi: 10.1093/hmg/ddv154
Brennan, M.; Csatayová, K.; Davies, S. G.; Fletcher, A. M.; Green, W. D.; Lee, J. A.; Roberts, P. M.; Russell, A. J.; Thomson, J. E.
Syntheses of dihydroconduramines (±)-B-1, (±)-E-1 and (±)-F-1 via diastereoselective epoxidation of N-protected 4-aminocyclohex-2-en-1-ols.
J. Org. Chem. 2015, doi: 10.1021/acs.joc.5b00716
Taylor, L.; Christou, I.; Kapellos, T. S.; Buchan, A.; Brodermann, M. H.; Gianella-Borradori, M.; Russell, A.; Iqbal, A. J.; Greaves, D. R.
Primary macrophage chemotaxis induced by cannabinoid receptor 2 agonists occurs independently of the CB2 receptor.
Scientific Rep. 2015, doi: 10.1038/srep10682
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Davies, S. G.; Kennewell, P. D.; Russell, A. J.; Seden, P. T.; Westwood, R.; Wynne, G. M.
Stemistry: The Control of Stem Cells in Situ Using Chemistry.
J. Med. Chem. 2015, 58, 2863-2894.
Davies, S. G.; Goddard, E. C.; Roberts, P. M.; Russell, A. J.; Thomson, J. E.
Enantiopure 3-amino substituted 1-indanones, 1-tetralones and 1-benzosuberones via Friedel-Crafts cyclisation of ω-aryl-β-benzamido acids.
Synlett 2015, doi:10.1055/s-0034-1380675
Brennan, M. B.; Davies, S. G.; Fletcher, A. M.; Lee, J. A.; Roberts, P. M.; Russell, A. J.; Thomson, J. E.
Epoxidation of trans-4-aminocyclohex-2-en-1-ol derivatives: competition of hydroxyl-directed and ammonium-directed pathways.
Aust. J. Chem. 2015, 68, 610-621.
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Gianella-Borradori, M.; Christou, I.; Bataille, C. J. R.; Cross, R. L.; Wynne, G. M.; Greaves, D. R.; Russell, A. J.
Ligand-based virtual screening identifies a family of selective cannabinoid receptor 2 agonists.
Bioorg. Med. Chem. 2015, 23, 241-263.
2014
Laurieri, N.; Kawamura, A.; Westwood, I. M.; Varney, A.; Morris, E.; Russell, A. J.; Stanley, L. A.; Sim, E.
Differences between murine arylamine N-acetyltransferase type 1 and human arylamine N-acetyltransferase type 2 defined by substrate specificity and inhibitor binding.
BMC Pharmacol. Toxicol. 2014, 15, 68.
Abuhammad, A.; Fullam, E.; Bhakta, S.; Russell, A. J.; Morris, G. M.; Finn, P. W.; Sim, E.
Exploration of Piperidinols as Potential Antitubercular Agents.
Molecules 2014, 19, 16274–16290.
Egleton, J. E.; Thinnes, C. C.; Seden, P. T.; Laurieri, N.; Lee, S. P.; Hadavizadeh, K. S.; Measures, A. R.; Jones, A. M.; Thompson, S.; Varney, A.; Wynne, G. M.; Ryan, A.; Sim, E.; Russell, A. J.
Structure-activity relationships and colorimetric properties of specific probes for the putative cancer biomarker human arylamine N-acetyltransferase 1.
Bioorg. Med. Chem. 2014, 22, 3030–3054.
Laurieri, N.; Dairou, J.; Egleton, J. E.; Stanley, L. A.; Russell, A. J.; Dupret, J. M.; Sim, E.; Rodrigues-Lima, F.
From Arylamine N-Acetyltransferase to Folate-Dependent Acetyl CoA Hydrolase: Impact of Folic Acid on the Activity of (HUMAN)NAT1 and Its Homologue (MOUSE)NAT2.
PLoS One 2014, 9, e96370.
2013
Lufino, M. M. P.; Silva, A. M.; Németh, A. H.; Alegre-Abarrategui J.; Russell A. J.; Wade-Martins, R. A
Novel Genomic DNA Reporter Model of Friedreich’s Ataxia Carrying Expanded GAA Repeats Identifies A New Frataxin Up-regulating Compound.
Human Mol. Genet. 2013, 22, 5173–5187.
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Russell, A. J.
Regenerative Medicinal Chemistry: The in Situ Control of Stem Cells.
ACS Med. Chem. Lett. 2013, 4, 365–368.
Claridge, T. D. W.; Davies, S. G.; Kruchinin, D.; Odell, B.; Roberts, P. M.; Russell, A. J.; Thomson, J. E.; Toms, S. M.
Solution phase structures of enantiopure and racemic lithium N-benzyl-N-(α-methylbenzyl)amide in THF: Low temperature Li and N NMR spectroscopic studies.
Tetrahedron Asymmetry 2013, 24, 947–952.
Laurieri, N.; Egleton, J.E.; Varney, A.; Thinnes, C. C.; Quevedo, C. E.; Seden, P.T.; Thompson, S.; Rodrigues-Lima, F.; Dairou, J.; Dupret, J.-M.; Russell, A. J.; Sim, E.
A Novel Color Change Mechanism for Breast Cancer Biomarker Detection: Naphthoquinones as Specific Ligands of Human Arylamine N-Acetyltransferase 1.
PLoS One 2013, 8, e70600.
Fullam, E.; Talbot, J.; Abuhammed, A.; Westwood, I.; Davies, S. G.; Russell, A. J.; Sim, E.
Design, synthesis and structure-activity relationships of 3,5-diaryl-1H-pyrazoles as inhibitors of arylamine N-acetyltransferase.
Bioorg. Med. Chem. Lett. 2013, 23, 2759–2764.
Hewings, D. S.; Fedorov, O.; Filippakopoulos, P.; Martin, S.; Picaud, S.; Tumber, A.; Wells, C.; Olcina, M. M.); Freeman, K.; Gill, A.; Ritchie, A. J.; Sheppard, D. W.; Russell, A. J.; Hammond, E. M.; Knapp, S.; Brennan, P. E.; Conway, S. J.
Optimization of 3,5-Dimethylisoxazole Derivatives as Potent Bromodomain Ligands.
J. Med. Chem. 2013, 56, 3217–3227.
2012
Abuhammad, A.; Fullam, E.; Lowe, E. D.; Staunton, D.; Kawamura, A.; Westwood, I. M.; Bhakta, S.; Garner, A. C.; Wilson, D. L.; Seden, P. T.; Davies, S. G.; Russell, A. J.; Garman, E. F.; Sim, E.
Piperidinols That Show Anti-Tubercular Activity as Inhibitors of Arylamine N-Acetyltransferase: An Essential Enzyme for Mycobacterial Survival Inside Macrophages.
PLoS One 2012, 7, e52790.
Davies, S. G.; Fletcher, A. M.; Lee, J. A.; Roberts, P. M.; Russell, A. J.; Taylor, R. J.; Thomson, A. D.; Thomson, J. E.
Polysubstituted Piperidines via Iodolactonization: Application to the Asymmetric Synthesis of (+)-Pseudodistomin D.
Org. Lett. 2012, 14, 1672–1675.
Davies, S. G.; Fletcher, A. M.; Hughes, D. G.; Lee, J. A.; Price, P. D.; Roberts, P. M.; Russell, A. J.; Smith, A. D.; Thomson, J. E.; Williams, O. M. H.
Asymmetric synthesis of piperidines and octahydroindolizines using a one-pot ring-closure/N-debenzylation procedure.
Tetrahedron 2011, 67, 9975–9992.
Li, J. L.; Sainson, R. C. A.; Oon, C. E.; Turley, H.; Leek, R.; Sheldon, H.; Bridges, E.; Shi, W.; Snell, C.; Bowden, E. T.; Wu, H. R.; Chowdhury, P. S.; Russell, A. J.; Montgomery, C. P.; Poulsom, R. and Harris, A. L.
DLL4-Notch Signaling Mediates Tumor Resistance to Anti-VEGF Therapy In Vivo.
Cancer Res. 2011, 71, 6073–6083.
Csatayova, K.; Davies, S. G.; Lee, J. A.; Roberts, P. M.; Russell, A. J.; Thomson, J. E.; Wilson, D. L.
Highly Diastereoselective and Stereodivergent Dihydroxylations of Acyclic Allylic Amines: Application to the Asymmetric Synthesis of 3,6-Dideoxy-3-amino-L-talose.
Org. Lett. 2011, 13, 2606–2609.
Westwood, I. M.; Kawamura, A.; Russell, A. J.; Sandy, J.; Davies S. G. and Sim, E.
Novel Small-Molecule Inhibitors of Arylamine N-Acetyltransferases: Drug Discovery by High Throughput Screening.
Combi. Chem. High Throughput Screening 2011, 14, 117–124.
Fullam, E.; Abuhammad, A.; Wilson, D. L.; Davies, S. G.; Russell, A. J. and Sim, E.
Analysis of beta-amino alcohols as inhibitors of the potential anti-tubercular target N-acetyltransferase.
Bioorg. Med. Chem. Lett. 2011, 21, 1185–1190.
Abraham, E.; Claridge, T. D. W.; Davies, S. G.; Odell, B.; Roberts, P. M.; Russell, A. J.; Smith, A. D.; Smith, L. J.; Storr, H. R.; Sweet, M. J.; Thompson, A. L.; Thomson, J. E.; Tranter, G. E.; Watkin, D. J.
A systematic study of the solid state and solution phase conformational preferences of beta-peptides derived from C(3)-alkyl substituted transpentacin derivatives.
Tetrahedron: Asymmetry 2011, 22, 69–100.
2010
Laurieri, N.; Crawford, M. H. J.; Kawamura, A.; Westwood, I. M.; Robinson, J.; Fletcher, A. M.; Davies, S. G.; Sim, E. and Russell, A. J.
Small Molecule Colorimetric Probes for Specific Detection of Human Arylamine N-Acetyltransferase 1, a Potential Breast Cancer Biomarker.
J. Am. Chem. Soc. 2010, 132, 3238–3239.
Csatayova, K.; Davies, S. G.; Lee, J. A.; Ling, K. B.; Roberts, P. M.; Russell, A. J.; Thomson, J. E.
Chemo- and diastereoselective cyclopropanation of allylic amines and carbamates.
Tetrahedron 2010, 66, 8420–8440.
Davies, S. G.; Ling, K. B.; Roberts, P. M.; Russell, A. J.; Thomson, J. E.; Woods, P. A.
The stereodivergent aziridination of allylic carbamates, amides and sulphonamides.
Tetrahedron 2010, 66, 6806–6813.
Csatayova, K.; Davies, S. G.; Lee, J. A.; Ling, K. B.; Roberts, P. M.; Russell, A. J.; Thomson, J. E.
Syntheses of trans-SCH-A and cis-SCH-A via a Stereodivergent Cyclopropanation Protocol.
Org. Lett. 2010, 12, 3152–3155.
Abraham, E.; Bailey, C. W.; Claridge, T. D. W.; Davies, S. G.; Ling, K. B.; Odell, B.; Rees, T. L.; Roberts, P. M.; Russell, A. J.; Smith, A. D.; Smith, L. J.; Storr, H. R.; Sweet, M. J.; Thompson, A. L.; Thomson, J. E.; Tranter, G. E.; Watkin, D. J.
A systematic study of the solid state and solution phase conformational preferences of beta-peptides derived from transpentacin.
Tetrahedron: Asymmetry 2010, 21, 1797–1815.
Cresswell, A. J.; Davies, S. G.; Lee, J. A.; Roberts, P. M.; Russell, A. J.; Thomson, J. E.; Tyte, M. J.
beta-Fluoroamphetamines via the Stereoselective Synthesis of Benzylic Fluorides.
Org. Lett. 2010, 12, 2936–2939.
Bentley, S. A.; Davies, S. G.; Lee, J. A.; Roberts, P. M.; Russell, A. J.; Thomson, J. E.; Toms, S. M.
Conjugate addition of lithium N-tert-butyldimethylsilyloxy-N-(alpha-methylbenzyl)amide: asymmetric synthesis of beta(2,2,3)-trisubstituted amino acids.
Tetrahedron 2010, 66, 4604–4620.
Westwood, I. M.; Bhakta, S.; Russell, A. J.; Fullam, E.; Anderton, M. C.; Kawamura, A.; Mulvaney, A. W.; Vickers, R. J.; Bhowruth, V.; Besra, G. S.; Lalvani, A.; Davies, S. G. and Sim, E.
Identification of arylamine N-acetyltransferase inhibitors as an approach towards novel anti-tuberculars.
Protein & Cell 2010, 1, 82-95.
Davies, S. G.; Hughes, D. G.; Price, P. D.; Roberts, P. M.; Russell, A. J.; Smith, A. D.; Thomson, J. E. And Williams, O. M. H.
Asymmetric Synthesis of Piperidines and Octahydroindolizines.
Synlett 2010, 567–570.
Bagal, S. K.; Davies, S. G.; Lee, J. A.; Roberts, P. M.; Russell, A. J.; Scott, P. M. and Thomson, J. E.
An Oxidation and Ring Contraction Approach to the Synthesis of (+/-)-1-Deoxynojirimycin and (+/-)-1-Deoxyaltronojirimycin.
Org. Lett. 2010, 12, 136–139.
2009
Bond, C. W.; Cresswell, A. J.; Davies, S. G.; Fletcher, A. M.; Kurosawa, W.; Lee, J. A.; Roberts, P. M.; Russell, A. J.; Smith, A. D. and Thomson, J. E.
Ammonium-Directed Oxidation of Cyclic Allylic and Homoallylic Amines.
J. Org. Chem. 2009, 74, 6735–6748.
Soncin, F.; Mohamet, L.; Eckardt, D.; Ritson, S.; Eastham, A. M.; Spencer, H.; Bobola, N.; Russell, A. J.; Davies, S. G.; Kemler, R.; Merry, C. L. R. and Ward, C. M.
Abrogation of E-cadherin mediated cell-cell contact in mouse embryonic stem cells results in reversible LIF-independent self-renewal.
Stem Cells 2009, 27, 2069–2080.
Wilkinson, R. N.; Gering, M.; Russell, A. J.; Davies, S. G.; Kimelman, D. and Patient, R.
Hedgehog and Bmp Polarize Hematopoietic Stem Cell Emergence in the Zebrafish Dorsal Aorta.
Dev. Cell 2009, 16, 909–916.
Davies, S. G.; Nicholson, R. L.; Price, P. D.; Roberts, P. M.; Russell, A. J.; Savory, E. D.; Smith, A. D. and Thomson, J. E.
Iodine-mediated ring-closing iodoamination with concomitant N-debenzylation for the asymmetric synthesis of polyhydroxylated pyrrolidines.
Tetrahedron: Asymmetry 2009, 20, 758–772.
Pettigrew, D. M.; Roversi, P.; Davies, S. G; Russell, A. J. and Lea, S. M.
Structural studies of the interaction between the Dr haemagglutinin DraE and derivatives of chloramphenicol.
Acta Cryst. D 2009, 65, 513–522
Aciro, C.; Davies, S. G.; Kurosawa, W.; Roberts, P. M.; Russell, A. J. and Thomson, J. E.
Highly diastereoselective anti-dihydroxylation of 3-N,N-dibenzylaminocyclohex-1-ene N-oxide.
Org. Lett. 2009, 11, 1333–1336.
Davies, S. G.; Durbin, M. J; Goddard, E. C.; Kelly, P. M.; Kurosawa, W.; Lee, J. A.; Nicholson, R. L.; Price, P. D.; Roberts, P. M.; Russell, A. J.; Scott, P. M. and Smith, A. D.
Double diastereoselective conjugate addition of homochiral lithium amides to homochiral α,β-unsaturated esters containing cis- and trans-dioxolane units.
Org. Biomol. Chem. 2009, 7, 761–776.
Russell, A. J.; Westwood, I. M.; Crawford, M. C.; Robinson, J.; Kawamura, A.; Redfield, C.; Lowe, E. D.; Laurieri, N.; Davies, S. G. and Sim, E.
Selective small molecule inhibitors of the potential breast cancer marker, human arylamine N-acetyltransferase 1, and its murine homologue, mouse arylamine N-acetyltransferase 2.
Bioorg. Med. Chem. 2009, 17, 905–918.
Davies, S. G.; Durbin, M. J.; Hartman, S. J. S.; Matsuno, A.; Roberts, P. M.; Russell, A. J.; Smith, A. D.; Thomson, J. E. and Toms, S. M.
Parallel kinetic resolution of tert-butyl (RS)-6-alkyl-cyclohex-1-ene-carboxylates for the asymmetric synthesis of 6-alkyl-substituted cishexacin derivatives.
Tetrahedron: Asymmetry 2009, 19, 2870–2881.
Case-Green, S. C.; Davies, S. G.; Roberts, P. M.; Russell, A. J. and Thomson, J. A.
Asymmetric synthesis of tetrahydrolipstatin and valilactone.
Tetrahedron: Asymmetry 2009, 19, 2870–2881.
Lack, N. A.; Kawamura, A.; Fullam, E.; Laurieri, N.; Beard, S.; Russell, A. J.; Evangelopoulos, D.; Westwood I. and Sim, E.
Temperature stability of proteins essential for the intracellular survival of Mycobacterium tuberculosis.
Biochem. J. 2009, 418, 369–378.
Torabi Kachoosangi, R.; Musameh, M. M.; Abu-Yousef, I.; Yousef, J. M.; Kanan, S. M.; Xiao, L.; Davies, S. G.; Russell, A. and Compton, R. G.
Carbon Nanotube - Ionic Liquid Composite Sensors and Biosensors.
Anal. Chem. 2009, 81, 435–442.
2008
Claridge, T. D. W.; Davies, S. G.; Lee, J. A.; Nicholson, R. L.; Roberts, P. M.; Russell, A. J.; Smith, A. D. and Toms, S. M.
Highly (E)-Selective Wadsworth-Emmons Reactions Promoted by Methylmagnesium Bromide.
Org. Lett. 2008, 10, 5437–5440.
Claridge, T. D. W.; Davies, S. G.; Polywka, M. E. C.; Roberts, P. M.; Russell, A. J.; Savory, E. D. and Smith, A. D.
“Pure by NMR?”
Org. Lett. 2008, 10, 5433–5436.
Aciro, C.; Davies, S. G.; Roberts, P. M.; Russell, A. J.; Smith, A. D. and Thomson, J. E.
Ammonium directed dihydroxylation: metal-free synthesis of the diastereoisomers of 3-amino-cyclohexane-1,2-diol.
Org. Biomol. Chem. 2008, 20, 3762–3770.
Aciro, C.; Claridge, T. D. W.; Davies, S. G.; Roberts, P. M.; Russell, A. J. and Thomson, J. E.
Ammonium directed dihydroxylation of 3-amino-cyclohex-1-enes: development of a metal-free dihydroxylation protocol.
Org. Biomol. Chem. 2008, 20, 3751–3761
Aciro, C.; Davies, S. G.; Garner, A. C.; Ishii, Y.; Key, M. S.; Ling, K. B.; Prasad, R. S.; Roberts, P. M.; Rodriguez-Solla, H.; O’Leary-Steele, C.; Russell, A. J.; Sanganee, H. J.; Savory, E. D.; Smith, A. D. and Thomson, J. E.
Stereoselective functionalisation of SuperQuat enamides: asymmetric synthesis of homochiral 1,2-diols and α-benzyloxy carbonyl compounds.
Tetrahedron 2008, 64, 9320–9344.
Musameh, M. M.; Kachoosangi, R. T.; Xiao, L.; Russell, A. and Compton, R. G.
Ionic liquid-carbon composite glucose biosensor.
Biosensors and Bioelectronics 2008, 24, 87–92.
Abraham, E.; Davies, S. G.; Docherty, A. J.; Ling, K. B.; Roberts, P. M.; Russell, A. J.; Thomson, J. E. and Toms, S. M.
Parallel kinetic resolution of methyl (RS)-5-tris(phenylthio)methyl-cyclopent-1-ene-carboxylate for the asymmetric synthesis of (1R,2S,5S)- and (1S,2R,5R)-5-methyl-cispentacin.
Tetrahedron: Asymmetry 2008, 19, 1356–1362.
Abraham, E.; Davies, S. G.; Roberts, P. M.; Russell, A. J. and Thomson, J. E.
Jaspine B (pachastrissamine) and 2-epi-jaspine B: synthesis and structural assignment.
Tetrahedron: Asymmetry 2008, 19, 1027–1047
Abraham, E.; Brock, E. A.; Candela-Lena, J. I.; Davies, S. G.; Georgiou, M.; Nicholson, R. L.; Perkins, J. H.; Roberts, P. M.; Russell, A. J.; Sánchez-Fernández, E. M.; Scott, P. M.; Smith, A. D. and Thomson, J. E.
Asymmetric synthesis of N,O,O,O-tetra-acetyl D-lyxo-phytosphingosine, jaspine B (pachastrissamine), 2-epi-jaspine B, and deoxoprosophylline via lithium amide conjugate addition.
Org. Biomol. Chem., 2008, 6, 1665–1673.
Davies, S. G.; Mortimer, D. A. B.; Mulvaney, A. W.; Russell, A. J.; Skarphedinsson, H.; Smith A. D. and Vickers, R. J.
An oxidatively-activated safety catch linker for solid phase synthesis.
Org. Biomol. Chem., 2008, 6, 1625–1634.
2007
Abraham, E.; Candela-Lena, J. I.; Davies, S. G.; Georgiou, M.; Nicholson, R. L.; Roberts, P. M.; Russell, A. J.; Sanchez-Fernandez, E. M.; Smith, A. D.; Thomson, J. E.
Asymmetric synthesis of N,O,O,O-tetra-acetyl D-lyxo-phytosphingosine, jaspine B (pachastrissamine) and its C(2)-epimer.
Tetrahedron: Asymmetry 2007, 18, 2510–2513.
Rogers, E. I.; Silvester, D. S.; Jones, S. E. W.; Aldous, L.; Hardacre, C.; Russell, A. J.; Davies, S. G.; Compton, R. G.
Electrochemical kinetics of AgAg+ and TMPDTMPD+ in the room-temperature ionic liquid [C(4)mpyrr][NTf2]; toward optimizing reference electrodes for voltammetry in RTILs.
J. Phys. Chem. C 2007, 111, 13957–13966.
Davies, S. G.; Mulvaney, A. W.; Russell, A. J.; Smith, A. D.
Parallel synthesis of homochiral beta-amino acids.
Tetrahedron: Asymmetry 2007, 18, 1554–1566.
Madikane, V. E.; Bhakta, S.; Russell, A. J.; Campbell, W. E.; Claridge, T. D. W.; Elisha, B. G.; Davies, S. G.; Smith, P.; Sim, E.
Inhibition of mycobacterial arylamine N-acetyltransferase contributes to anti-mycobacterial activity of Warburgia salutaris.
Bioorg. Med. Chem. 2007, 15, 3579–3586.
Davies, S. G.; Ling, K. B.; Roberts, P. M.; Russell, A. J.; Thomson, J. E.
Diastereoselective Simmons-Smith cyclopropanations of allylic amines and carbamates.
Chem. Commun. 2007, 39, 4029–4031.
Beddow, J. E.; Davies, S. G.; Ling, K. B.; Roberts, P. M.; Russell, A. J.; Smith, A. D.; Thomson, J. E.
Asymmetric synthesis of beta(2)-amino acids: 2-substituted-3-aminopropanoic acids from N-acryloyl SuperQuat derivatives.
Org. Biomol. Chem. 2007, 5, 2812–2825.
Davies, S. G.; Russell, A. J.; Sheppard, R. L.; Smith, A. D.; Thomson, J. E.
Evaluating beta-amino acids as enantioselective organocatalysts of the Hajos-Parrish-Eder-Sauer-Wiechert reaction.
Org. Biomol. Chem. 2007, 5, 3190–3200.
Cailleau, T.; Cooke, J. W. B.; Davies, S. G.; Ling, K. B.; Naylor, A.; Nicholson, R. L.; Price, P. D.; Roberts, P. M.; Russell, A. J.; Smith, A. D.; Thomson, J. E.
Asymmetric synthesis of beta-amino-gamma-substituted-gamma-butyrolactones: double diastereoselective conjugate addition of homochiral lithium amides to homochiral alpha,beta-unsaturated esters.
Org. Biomol. Chem. 2007, 5, 3922–3931.
pre-2007
Davies, S. G.; Garrido, N. M.; Kruchinin, D.; Ichihara, O.; Kotchie, L. J.; Price, P. D.; Mortimer, A. J. P.; Russell, A. J.; Smith, A. D.
Homochiral lithium amides for the asymmetric synthesis of beta-amino acids.
Tetrahedron: Asymmetry 2006, 17, 1793–1811.
Candela-Lena, J. I.; Davies, S. G.; Roberts, P. M.; Roux, B.; Russell, A. J.; Sanchez-Fernandez, E. M.; Smith, A. D.
Asymmetric synthesis of alpha-mercapto-beta-amino acid derivatives: application to the synthesis of polysubstituted thiomorpholines.
Tetrahedron: Asymmetry 2006, 17, 1135–1145.
Westwood, I. M.; Kawamura, A.; Fullam, E.; Russell, A. J.; Davies, S. G.; Sim, E.
Structure and mechanism of arylamine N-acetyltransferases.
Curr. Top. Med. Chem. 2006, 6, 1641–1654.
Book Chapters
Davies, S. G. and Russell, A. J.
Chemical Biology of Stem Cell Modulation
New Frontiers in Chemical Biology, Bunnage, M. E. (Ed.)
Royal Society of Chemistry, 2011, ISBN: 184973125X.
Russell, A. J. and Wynne, G. M.
Drug Discovery Approaches for Rare Neuromuscular Diseases
Orphan Drugs and Rare Diseases, Palmer, M. and Pryde, D. (Ed.)
Royal Society of Chemistry, 2014, ISBN: 978-1-84973-806-4.